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KMID : 0869220200240020099
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Journal of Korean Geriatric Psychiatry
2020 Volume.24 No. 2 p.99 ~ p.102
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Effect of Fetal Sex Hormone on the Development of Alzheimer’s Disease in Woman: A Cross-Sectional Study Using 2D/4D Digit Length Ratio
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Kang Tae-Uk
Lee Young-Min
Park Je-Min
Lee Byung-Dae
Moon Eun-Soo
Jeong Hee-Jeong
Kim Soo-Yeon
Lee Kang-Yoon
Suh Hwa-Gyu
Chung Young-In
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Abstract
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Objective: The purpose of this study is to investigate an association between sex-hormone exposure during fetal period and the development of Alzheimer’s disease (AD).
Methods: Twenty four AD patients and 25 normal controls were included from Memory Impairment Clinic of Pusan National University Hospital in Korea. Subjects are measured the ratio of the length of the second to the fourth digit (2D/4D) to estimate fetal sex-hormone exposure. Analysis of covariance was used to investigate an association between fetal sex-hormone exposure and the development of AD after adjusting age, education level, Korean Mini-Mental Status Examination and head circumference.
Results: We found that the females with AD had significantly lower 2D/4D ratios than the female controls. In the females with AD, the 2D/4D ratios in the left hand was 0.021 and 0.017 in the right hand compared with the controls.
Conclusion: Our findings suggest that the development of AD in female may be related with higher testosterone and lower estrogen exposure during fetal period.
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KEYWORD
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Alzheimer′s disease, Fetal sex hormone, 2D/4D ratios
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